To sedating

When drugs are used as adjuncts, decreasing the dose of each respective drug is important, so as to decrease the incidence of adverse effects.

Be cautious when giving a hepatically metabolized benzodiazepine (eg, midazolam) to a patient with cirrhosis.This is accomplished along a continuum of sedation levels: Prior to the administration of medications, clinicians must know the level of sedation required for a given procedure and the appropriate dose of the pharmacologic agent or agents chosen.This determines the equipment that one should have readily available prior to starting the procedure.When the p H is less than 4, it is water soluble and the chance of pain at the injection site is lowered.Unlike other benzodiazepines, midazolam becomes lipophilic at a p H greater than 4.

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